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Updated: Mar 23, 2026

Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
10:24

Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry

Published on: June 7, 2018

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還元性カルボキシル化は,アンカージ独立成長中の酸化還元性ホメオスタシスをサポートする

Lei Jiang1, Alexander A Shestov2, Pamela Swain3

  • 1Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, Texas 75390-8502, USA.

Nature
|April 7, 2016
PubMed
まとめ

癌細胞は代謝を変化させることで 細胞結合なしに成長します この研究では,細胞性同位酸脱水酵素-1 (IDH1) が反応性酸素種 (ROS) を制御し,アンカレージ独立の癌細胞の腫瘍増殖をサポートする新しい経路が明らかになりました.

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