ヒトの微生物群からの独特な種のピルス

Qingping Xu¹, Mikio Shoji², Satoshi Shibata²

¹Joint Center for Structural Genomics, http://www.jcsg.org; SLAC National Accelerator Laboratory, Stanford Synchrotron Radiation Lightsource, Menlo Park, CA 94025, USA.

Cell

|April 12, 2016

まとめ

研究者はヒトの微生物群から独特の構造と組み立てを発見しましたこれらのバクテリアのピリは,以前から知られていたタイプとは異なる新しい糸交換メカニズムを使用しています.

科学分野:

微生物学と構造生物学
バクテリアの粘着とウイルス性因子

背景:

粘着と毒性に関与する重要な細菌の表面付属体です.
ヒトの微生物群におけるバクテロイド種のピリの構造と組成は,以前は特徴づけられていなかった.

研究の目的:

20個のバクテロイドの分子構造を解明する.
これらのピリンが機能するピリに組み合わされるメカニズムを決定する.

主な方法:

柱の3次元構造を決定するために,X線結晶学が採用されました.
ポリメリゼーションと組み立てプロセスを調査するために生化学的測定が行われました.
既知のピルスシステムとの比較分析が行われました.

主要な成果:

2つのトランスチレチンのような繰り返しを持つ一般的なギリシャキーβサンドイッチの折りたたみがピリン超ファミリー全体で特定されました.
ピルスの組み立ては,タンパク質アースによるN端 β鎖の除去と水性溝結合を含む鎖交換メカニズムによって起こります.
アクセサリーピールは,端と底で,組み立て開始と終了のための特殊な構造を示します.

結論:

Bacteroidia piliは,他の特徴づけられた細菌 piliとは異なる独特の生体生成機構を有しています.
この発見は独特の組み立て戦略を持つ新種の細菌の群れを明らかにしています
これらのメカニズムを理解することで,ヒトの微生物群内の細菌の相互作用に関する洞察が得られます.

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