骨髄の異なる血管は,血液形成を差異的に調節する
Tomer Itkin1, Shiri Gur-Cohen1, Joel A Spencer2,3
1Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Nature
|April 14, 2016
まとめ
骨髄の血管は幹細胞の維持と 免疫細胞の密輸を制御しています 静脈血管は幹細胞を保護し,浸透性シヌソイドは免疫細胞の移動と幹細胞の活性化を促進します.
科学分野:
- 血液学
- 血管生物学
- 幹細胞生物学
背景:
- 骨髄内皮細胞 (BMEC) は白血球の流通と造血幹細胞と原始細胞 (HSPC) の維持を管理する.
- これらのBMEC機能をバランスさせる特定のメカニズムと血管の位置は不明である.
研究 の 目的:
- 骨髄の異なる血管タイプが,HSPCの維持と白血球の流通をどのように異なる形で調節するかを調査する.
- これらのプロセスが同じ血管部位で起こるかどうかを判断する.
主な方法:
- 異なる骨髄血管の比較分析
- 血管の浸透性とHSPCと白血球の流通に対する影響の評価
- HSPCにおける活性酸素種 (ROS) レベルの評価
主要な成果:
- 浸透性の低い動脈血管は,低活性酸素種 (ROS) の状態で血液形成性幹細胞 (HSC) を維持する.
- 高度浸透性のあるシヌソイドはHSPCの活性化を促進し,白血球の密輸の主な場所です.
- シヌソイドのプラズマ曝露の増加は,HSPC ROSを上昇させ,移住と分化を促進するが,長期的な生存と再集団化を阻害する.
結論:
- 骨髄幹細胞の維持と白血球の流通は,異なる透かし性を有する異なる血管ニッチによって制御されます.
- 血管の透過性はHSPCの機能に大きく影響し,幹細胞移植と動員戦略にも影響を及ぼします.
さらに関連する動画
08:34Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
Published on: September 28, 2022
6.1K
09:07A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
Published on: December 16, 2022
4.1K
関連する概念動画
Overview of Hematopoiesis
11.2K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
11.2K
Hematopoiesis
9.7K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
9.7K
Regulation of Hematopoietic Stem Cells
4.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.3K
Regulation of Angiogenesis and Blood Supply
3.9K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.9K
Blood and Nerve Supply to the Bones
14.6K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
14.6K
Role of Hematopoietic Growth Factors
4.3K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
4.3K
