ホビットとBlimp1は,リンパ球の組織在留の普遍的な転写プログラムを指示します

Laura K Mackay¹, Martina Minnich², Natasja A M Kragten³

¹Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Melbourne, Australia. lkmackay@unimelb.edu.au kallies@wehi.edu.au k.vangisbergen@sanquin.nl.

Science (New York, N.Y.)

|April 23, 2016

まとめ

トランスクリプション因子HobitとBlimp1は,記憶T細胞 (Trm) と他の組織に居住するリンパ球の組織保持に不可欠であり,再感染に対する即時の保護を保証します.

科学分野:

免疫学
細胞生物学
トランスクリプション規則

背景:

組織内記憶T (Trm) 細胞は組織内に存在し,再感染に対する迅速な保護を提供します.
TRM細胞保持はCD69のアップレギュレーションとエグレス分子のダウンレギュレーションを伴うが,主要なレギュレーターは不明であった.

研究の目的:

Trm細胞の組織保持に責任のある転写レギュレータを特定する.
ホビットとBlimp1のTrm細胞の発達と組織在留の役割を調査する.

主な方法:

Trm細胞における転写因子発現の分析
マウスでの遺伝子研究で,Trm細胞および他の組織内レジデントリンパ球におけるHobitとBlimp1の機能を評価した.

主要な成果:

ホビットは特異的にTrm細胞で調節されます.
ホビット-ブリンプ1モジュールは皮膚,腸,肝臓,腎臓の TRM細胞発育に不可欠です.
このモジュールはNKT細胞やNK細胞のような他の組織に居住するリンパ球を調節します.

結論:

ホビットとBlimp1は,多様なリンパ球集団における組織保持の中央調節体として特定されています.
ホビット-ブリンプ1が介在する共同の転写プログラムが組織在留を制御する
この発見は,組織内の免疫監視を維持するための洞察を提供します.

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