訓練された免疫: 健康と病気に関する生まれつきの免疫記憶のプログラム

Mihai G Netea¹, Leo A B Joosten², Eicke Latz³

¹Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands. mihai.netea@radboudumc.nl.

Science (New York, N.Y.)

|April 23, 2016

まとめ

遺伝的変化なしに再感染に対する抵抗力を提供しますこのエピジェネティック再プログラミングはワクチンや免疫疾患の治療に新たな道を開きます

科学分野:

免疫学
エピジェネティクス
感染症

背景:

適応免疫は伝統的に免疫学的記憶の唯一のメカニズムと考えられていた.
最近の発見はこの見解に異議を唱え生まれつきの免疫が果たす役割を強調しています

研究の目的:

"訓練された免疫"や "生まれつきの免疫記憶"の概念を探求する.
生まれつきの免疫記憶のメカニズムと意味を理解する

主な方法:

トレーニングされた免疫の基礎となるメカニズムとして,エピジェネティック再プログラミングを調査した.
遺伝子の発現と細胞生理の持続的な変化を調べました

主要な成果:

生まれつきの免疫が記憶を確立し再感染への抵抗力を提供することを示しました
適応免疫における遺伝的変化とは異なる重要なプロセスとして表遺伝的再プログラミングを特定した.

結論:

トレーニングされた免疫の発見は免疫記憶の理解を広げました
潜在的応用には,免疫不全や炎症性疾患に対する新しいワクチン戦略と治療法が含まれます.

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