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Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages
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内生的なカスパース-11リガンドは,生きているデンドリット細胞からインタールキン-1の放出を誘発する

Ivan Zanoni1, Yunhao Tan2, Marco Di Gioia2

  • 1Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA. Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy. Unit of Cell Signalling and Innate Immunity, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.

Science (New York, N.Y.)
|April 23, 2016
PubMed
まとめ

デンドリット細胞 (DCs) は"過剰活性"状態に入り,免疫反応を強める. この状態は 微生物産物や酸化したリン脂によって引き起こされ 単純なオン/オフ信号を超えた 微妙な先天的な免疫を明らかにします

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