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Updated: Mar 22, 2026

A Reporter Based Cellular Assay for Monitoring Splicing Efficiency
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Rbfoxタンパク質は,大型多タンパク質複合体 (LASR) の一部としてスプライシングを調節する

Andrey Damianov1, Yi Ying2, Chia-Ho Lin1

  • 1Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Cell
|April 23, 2016
PubMed
まとめ

Rbfoxタンパク質は,脳内の多くのスプライシングレギュレータ (LASR) と相互作用する. hnRNP Mを含むこの複合体は,代替スプライシングに影響を与え,神経疾患の研究に影響を及ぼします.

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RNA Splicing01:32

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In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
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