関連する実験動画

Updated: Mar 22, 2026

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans
08:12

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans

Published on: October 5, 2020

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小分子RAS模倣剤は,RASとエフェクタタンパク質の結合を妨害し,シグナリングをブロックする

Sai Krishna Athuluri-Divakar1, Rodrigo Vasquez-Del Carpio1, Kaushik Dutta2

  • 1Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA.

Cell
|April 23, 2016
PubMed
まとめ

新薬であるリゴセルチブは,RAS結合ドメイン (RBD) との相互作用を阻害することで,癌を誘発するRAS信号伝達を抑制する. この障害はRAS-RAF-MEKのような 重要な経路に影響を与え 様々な癌の治療戦略を 提供します

キーワード:
MAPKPI3K についてRAF (イギリス空軍)RAS についてRAS 結合領域リゴセルチブ

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Author Spotlight: Developing Tools to Tune the Activity of Tyrosine Phosphatases06:56

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The Ras Gene02:38

The Ras Gene

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Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
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