健康な高齢者集団の全ゲノムシーケンシング
Galina A Erikson1, Dale L Bodian2, Manuel Rueda1
1The Scripps Translational Science Institute, Scripps Health, and The Scripps Research Institute, La Jolla, CA 92037, USA.
Cell
|April 27, 2016
まとめ
健康的な老化は 特殊な長寿とは異なり アルツハイマー病や冠動脈疾患などの 遺伝的易感性の低下を伴います 遺伝的要因は 認知機能の低下を 防ぎます 病気に抵抗することが 鍵となるのです
科学分野:
- 遺伝学
- ゲロントロジー
- 病気 の 予防
背景:
- 特殊な長寿に関する研究は,年齢に関連する病気に対する遺伝的保護が限られていることを明らかにしました.
- 健康的な老化を医学的な介入なしに 病気のない老化と定義することは公衆衛生にとって極めて重要です
研究 の 目的:
- 健康的な老化の遺伝的基盤を 特殊な長寿とは異なる現象として調査する.
- 病気のない老化と,老化関連疾患に対する耐性に関連した遺伝的要因を特定する.
主な方法:
- 健康的な老化を示す個体のゲノムシーケンス
- 共通と希少な遺伝子変異の分析
- 遺伝子のプロフィールと 特殊な長寿集団の比較
主要な成果:
- 健康的な老化は 既知の長寿変異とは関係ありませんが アルツハイマー病や冠動脈疾患に対する遺伝的感受性の低下を示しています
- 病原性変異の減少は観察されず,疾患耐性因子を示唆した.
- 共通の変異と珍しい変異の遺伝的関連は 認知機能低下に対する保護を暗示しています
結論:
- 健康的な老化は 特殊な長寿とは重なり合うが 異なる現象です
- 健康的な老化に寄与する遺伝的要因には 認知機能の低下やその他の老化関連疾患に対する保護が含まれます
- これらの発見を検証するには,さらなる複製研究が必要である.
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