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Inner Mitochondrial Membrane Sensitivity to Na+ Reveals Partially Segmented Functional CoQ Pools
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NAD+/NADH比の操作により,ミトコンドリアの電子輸送鎖の補足

Denis V Titov1, Valentin Cracan1, Russell P Goodman2

  • 1Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA. Department of Systems Biology, Harvard Medical School, Boston, MA, USA. Broad Institute, Cambridge, MA, USA.

Science (New York, N.Y.)
|April 29, 2016
PubMed
まとめ

電子輸送チェーン (ETC) の機能不全が病気を引き起こす. この研究では,LbNOX酵素を用いたヒト細胞のNAD+/NADH比の増加が代謝問題を修正し,還元ストレスがミトコンドリア疾患に寄与することを示唆しています.

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