生命の初期に微生物群によるコロニー化が免疫系を形作る方法
Thomas Gensollen1, Shankar S Iyer1, Dennis L Kasper2
1Division of Gastroenterology, Hepatology, and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
まとめ
早期の乳児の微生物の植民は 免疫系を形作り 終身的な健康に影響します この臨界期間の障害は 免疫機能の欠陥や 炎症性腸疾患,アレルギー,喘息などの 病気を引き起こす可能性があります
科学分野:
- 免疫学
- 微生物学
- 発達生物学
背景:
- 乳児の微生物のコロニー化は 免疫系の発達に不可欠です
- 早期の免疫教育は 健康と病気の感受性に 永続的な影響を及ぼします
- 特定の発達期,または"機会の窓"は宿主-共生相互作用にとって重要です.
研究 の 目的:
- 免疫システムの発達における 早期の微生物の植民地の役割を議論する.
- 乳幼児の免疫教育に 重要な時期を強調するためです
- 宿主との交互作用が乱れた場合の 長期的な影響を調査する.
主な方法:
- 初期の発達における宿主-微生物の相互作用に関する最近の科学文献のレビュー.
- 免疫システムの訓練のための重要なウィンドウを定義する研究の分析.
- 免疫耐性や疾患発症に対する微生物の影響について
主要な成果:
- 早期の微生物植民は 哺乳類の免疫系を 大きく教育します
- 臨界期間の宿主との相互作用の障害は,永続的な免疫欠陥を引き起こす可能性があります.
- IBD,アレルギー,喘息などの病気に対する耐性や感受性の発達に影響します.
結論:
- 早期の発達における"機会の窓"は 免疫プログラムにとって極めて重要です
- 長期の免疫健康を確立するために 最適な微生物のコロニー化は不可欠です
- 早期の微生物被曝を標的とした介入は 免疫関連疾患を予防することができます
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