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Updated: Mar 21, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
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骨髄細胞に由来するVEGFは,脳のグルコース吸収を維持し,肥満における認知障害を制限する

Alexander Jais1, Maite Solas1, Heiko Backes2

  • 1Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Joseph Stelzmann Strasse 26, 50931 Cologne, Germany.

Cell
|May 3, 2016
PubMed
まとめ

脂肪が多い食事は,最初は脳血管のグルコーストランスポーター-1 (GLUT-1) を低下させることで,脳のグルコース吸収を減少させます. マクロファージが分泌する血管内皮成長因子 (VEGF) は後にこの吸収を回復し,肥満における認知低下を防ぎます.

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