ベースリンパ節における運動速度に対する対極的および双方向制御
Eric A Yttri1, Joshua T Dudman1
1Janelia Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA.
Nature
|May 3, 2016
まとめ
ベースリンパ節
科学分野:
- 神経科学
- モーター コントロール
- 行動の可塑性
背景:
- ベース・ギャングリアは 目標に導かれた行動に対して 報酬の信号を送る運動回路を統合します
- 背筋筋の直接的・間接的経路は 行動選択に関与する.
- 運動運動の精製における活動依存性可塑性の役割は不明である.
研究 の 目的:
- 運動動態学における学習された変化のために,基礎臓の活動に依存した可塑性が十分であるかどうかを調査する.
- 移動速度を双方向的に制御できるかどうかを判断する.
主な方法:
- 移動中の閉ループで提供されるマウスの細胞型特異的刺激
- 学習された行動の変化におけるドーパミンの役割を評価するために,ドーパミンのアンタゴニストを使用する.
主要な成果:
- 直接的または間接的な経路での活動は,移動速度の特定の持続的な変化を誘導するのに十分でした.
- これらの速度の変化は学習を表し,試験で蓄積され,刺激停止後に持続しました.
- ドーパミン 反抗薬は 学習した行動の変化を無効にしました
結論:
- ベースリンパ節の直接的・間接的な経路は 運動速度を双方向的に制御します
- 運動運動の特定の柔軟な制御をベースリンパ節によって示しています.
- これらの経路における活動に依存する可塑性は,運動速度の学習された調整の基礎となっています.
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