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ケタミン代謝産物のNMDAR抑制による抗うつ作用

Panos Zanos1, Ruin Moaddel2, Patrick J Morris3

  • 1Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

Nature
|May 5, 2016
PubMed
まとめ

ケタミンの抗うつ作用は,その代謝物であるヒドロキシノルケタミン (HNK) に依存しています. (2R,6R) - HNKエナティオメアは,NMDAR抑制ではなくAMPA受容体活性化による抗うつ作用を示し,ケタミンを含まない.

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