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Updated: Mar 21, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.7K

タンパク質のホモオリゴーマーをモジュール型水素結合ネットワーク介的特異性で設計する

Scott E Boyken1, Zibo Chen2, Benjamin Groves3

  • 1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. Institute for Protein Design, University of Washington, Seattle, WA 98195, USA. Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

Science (New York, N.Y.)
|May 7, 2016
PubMed
まとめ

科学者たちは特定の相互作用のために水素結合を用いて 新しいタンパク質構造を設計した. このアプローチは合成生物学のための 新しいタンパク質のデザインを作り タンパク質が相互作用する 新しい方法を明らかにします

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Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
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