皮膚 に 住む 微生物: 永遠 の 友
Pieter C Dorrestein1, Richard L Gallo2, Rob Knight3
1Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA; UC San Diego Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
Cell
|May 7, 2016
まとめ
人間の皮膚の微生物のコミュニティは 主に環境ではなく個人に左右されます この研究では 長期の安定性要因を明らかにするために 皮膚のメタゲノムをマッピングしています
科学分野:
- 微生物学
- ゲノミクス
- 人間の微生物群
背景:
- 人間の皮膚の微生物群は 健康や病気に 重要な役割を果たします
- 皮膚の微生物群の安定性や要因を理解することは 標的を絞った介入の開発に不可欠です
- 以前の研究では皮膚の微生物の組成を調べましたが 長期的なダイナミクスは理解されていないままです
研究 の 目的:
- 人間の皮膚メタゲノムの 時間の安定性を調べるためだ
- 時間の経過とともに皮膚の微生物群の組成に影響を与える主な要因を特定する.
- 皮膚の微生物群の回復力や適応力についての洞察を提供するためです
主な方法:
- 長期間に渡って皮膚サンプルをメタゲノム解析
- 微生物コミュニティの構成と多様性を評価するためのバイオ情報分析
- 宿主特異的および環境要因の影響を決定する統計的モデリング.
主要な成果:
- 皮膚の微生物コミュニティの構成は 時間の経過とともに 驚くほど安定しています
- 環境の影響よりも宿主特有の要因が 微生物コミュニティ構造の支配的な要因であることが判明しました
- 皮膚メタゲノムの個体間での有意な変化が観察されました.
結論:
- ヒトの皮膚の微生物群は 主に宿主によって決定される 高いレベルの 個人の安定性を表しています
- これらの発見は皮膚の健康,病原性,および微生物群ベースの治療法の開発の理解に意味があります.
- 将来の研究は,皮膚の微生物集団の集合を制御する特定の宿主因子を明らかにすることに焦点を当てるべきです.
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