人間の皮膚の微生物群の時間的な安定性
Julia Oh1, Allyson L Byrd2, Morgan Park3
1Translational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Cell
|May 7, 2016
まとめ
細菌,真菌,ウイルスを含むヒトの皮膚の微生物群は 時間の経過とともに 驚くほど安定しており 体の位置や個々の要因によって 影響を受けます 微生物を常に取り戻すのではなく 維持する傾向があります
科学分野:
- 微生物学
- 人間の微生物群の研究
- エコロジー
背景:
- 人間の皮膚の微生物群の構成は 生物地理的要因と宿主の個性によって影響を受けます
- これらの微生物コミュニティの安定性を理解することは ホストと微生物の相互作用と健康を 解読するのに不可欠です
研究 の 目的:
- 人間の皮膚の微生物群 (細菌,真菌,ウイルス群) の長期間 (数ヶ月から数年間) の安定性を調査する.
- 皮膚の微生物コミュニティの安定性を形成する際に身体部位,宿主の個性,および系統遺伝子の役割を決定する.
主な方法:
- 皮膚の縦断サンプルからメタゲノムシーケンスデータを生成する.
- バクテリア,真菌,ウイルスコミュニティのマルチキングダム,参照ベースの分析.
- 微生物の動態を評価するために,株と単核酸の変異レベル分析.
主要な成果:
- 皮膚の微生物群は環境への曝露にもかかわらず,時間の経過とともに著しい安定性を示した.
- 体の部位 (例えば,足の部位がより変異性を示す),宿主の個性,および系統形成は安定性の重要な決定因子であった.
- ユカリオットウイルスは,サイト特異性が低い一時的なコロニゼーションパターンを示した.
- 菌株と単一核酸変種レベルでの分析は,個人がその一般的な皮膚微生物を維持することを示した.
結論:
- 人間の皮膚の微生物群は 顕著な縦方向の安定性を示し 強い植民抵抗性メカニズムを示唆しています
- ホストの個性は,皮膚の微生物コミュニティの維持に重要な役割を果たします.
- 発見は,微生物の自家化という概念を支持し,病気に関連した微生物群の変化に関する臨床研究に意味を持っています.
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