リウマチ性関節炎
Josef S Smolen1, Daniel Aletaha2, Iain B McInnes3
1Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria; 2nd Department of Medicine, Hietzing Hospital Vienna, Vienna, Austria.
Lancet (London, England)
|May 10, 2016
まとめ
リウマチ性関節炎 (RA) の早期診断は,特にリスク因子のある患者にとって,効果的な治療に不可欠です. 現在の戦略は,病気の活性をモニタリングし,様々な病気を修正する抗レウマティック薬を使用することを含みますが,反応しない人に対して新しい治療法が必要です.
科学分野:
- リウマトロジ
- 免疫学
- 遺伝学
背景:
- リウマチ性関節炎 (RA) は慢性的な炎症性関節疾患で,軟骨/骨の損傷と障害を引き起こす.
- 早期診断とリスク因子の特定は RA の成功管理に不可欠です
- 進歩にもかかわらず 多くのRA患者は既存の治療法に反応せず 新しい治療法の必要性を強調しています
研究 の 目的:
- リウマチ性関節炎 (RA) に関する最新の洞察を提供する.
- 遺伝学,病因学,病理生理学,流行病学,評価,およびRAの治療戦略をカバーする.
- RA の患者さんのケアにおける満たされていないニーズを特定する.
主な方法:
- リウマチ性関節炎 (RA) に関する現在の科学文献のレビュー
- 遺伝学,病因学,病理生理学,流行病学の分析
- 現在の評価ツールと治療薬の評価
- 治療戦略と満たされていないニーズについての議論
主要な成果:
- RAの管理には 病気の活動量測定と 治療から標的までの戦略が含まれます
- 従来の生物学的および新しい非生物学的疾患修正抗レウマティック薬が使用されています.
- 寛解または低疾患の活動が達成された後に投与量を減らすことを検討します.
結論:
- RAの治療は改善されていますが,治療に反応しない患者には,まだ満たされていない需要が残っています.
- RAの遺伝学,病理生理学,新しい治療法に関する研究を継続することは不可欠です.
- RAの治療戦略を最適化するには,早期診断とパーソナライズされた治療を含む包括的なアプローチが必要です.
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