多刺激応答性によるピラーによるヒドロゲルの劇的に促進された腫れ[6]
Mengfei Ni1, Ning Zhang1, Wei Xia1
1Key Laboratory of Mesoscopic Chemistry of MOE, Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing, 210023, China.
Journal of the American Chemical Society
|May 10, 2016
まとめ
この研究では,水溶性柱 [6] アレンの溶液で劇的に膨らむフェロセンのグループを持つスマートヒドロゲルを提示しています. この新しい材料は,多刺激反応性と,pH反応性薬剤投与アプリケーションの可能性を示しています.
科学分野:
- 材料科学
- ポリマー化学
- 超分子化学
背景:
- ハイドロゲルの膨らみと縮小は アクチュエータや薬剤投与などの用途に不可欠です
- スマートヒドロゲルは,高度な機能のために調整可能な性質を提供します.
研究 の 目的:
- フェロセンのグループを組み込んだ 新しいスマート・ヒドロゲルを製造する
- 水溶性ピラーアレン (WP6) 溶液におけるヒドロゲルの腫れ反応を調査する.
- 様々な刺激に対するヒドロゲルの反応と 薬の投与の可能性を調査する
主な方法:
- ペンダントフェロセンのグループで機能化されたポリマーネットワークのヒドロゲルの製造.
- 水溶性柱[6]アレン (WP6) の水溶性溶液にヒドロゲルを浸す.
- ハイドロゲルの腫れ,多刺激反応 (温度,pH,リドックス,競合するゲスト) と薬の放出能力の評価.
主要な成果:
- 水素ゲルは,WP6-フェロセンのインクルージョン複合体の形成により,WP6溶液で約11倍重量増加を示した.
- 膨らんだヒドロゲルは 温度,pH,酸化還元条件,そして競争的なゲストに 反応を示した.
- スマートヒドロゲルは,pHに対応する薬剤の放出アプリケーションの可能性を示した.
結論:
- 鉄素を含む新型ヒドロゲルが成功して合成された.
- ハイドロゲルの有意な腫れと多刺激反応は,WP6との超分子相互作用に起因する.
- このスマート・ヒドロゲルは 先進的な応用が期待されます 特に制御された薬物投与システムです
関連する概念動画
02:34Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration
The rate of acid-catalyzed hydration of alkenes depends on the alkene's structure, as the presence of alkyl substituents at the double bond can significantly influence the rate.
01:17Thermal Electrocyclic Reactions: Stereochemistry
The stereochemistry of electrocyclic reactions is strongly influenced by the orbital symmetry of the polyene HOMO. Under thermal conditions, the reaction proceeds via the ground-state HOMO.
Selection Rules: Thermal Activation
Conjugated systems containing an even number of π-electron pairs undergo a conrotatory ring closure. For example, thermal electrocyclization of (2E,4E)-2,4-hexadiene, a conjugated diene containing two π-electron pairs, gives trans-3,4-dimethylcyclobutene.
Selection Rules: Thermal Activation
Conjugated systems containing an even number of π-electron pairs undergo a conrotatory ring closure. For example, thermal electrocyclization of (2E,4E)-2,4-hexadiene, a conjugated diene containing two π-electron pairs, gives trans-3,4-dimethylcyclobutene.
01:26Photochemical Electrocyclic Reactions: Stereochemistry
The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation
Selection Rules: Photochemical Activation
![[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2Ffiles%2Fmedia%2Fscience-education%2Fscience-education-thumbs%2F12417.jpg&w=3840&q=75)
01:16[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
01:29Diels–Alder Reaction: Characteristics of Dienes
The Diels–Alder reaction brings together a diene and a dienophile to form a six-membered ring. Both components have unique characteristics that influence the rate of the reaction.
Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is more stable, the...
Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is more stable, the...
01:29Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
Diels–Alder reactions between cyclic dienes locked in an s-cis configuration and dienophiles yield bridged bicyclic products.