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Updated: Mar 21, 2026

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p22phox C242T シングルヌクレオチドポリモルフィズム 内皮細胞と血管の炎症性酸化損傷を抑制する

Daniel N Meijles1, Lampson M Fan1, Maziah M Ghazaly1

  • 1From Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, UK (D.N.M., G.B., J.-M.L.); Faculty of Engineering and Physical Sciences, University of Surrey, UK (D.N.M., M.M.G., B.H.); Department of Cardiology, Royal Berkshire Hospital, UK (L.M.F.); and Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Germany (M.K.).

Circulation
|May 11, 2016
PubMed
まとめ

p22 ((phox) のC242TポリモルフィズムはNADPH酸化酵素の構造を変え,Nox2の活性化と炎症を軽減する. この遺伝的変異は 心血管疾患から自然に 保護されるかもしれません

キーワード:
NADPH酸化酵素血管 血管エンドセリウム遺伝学炎症構造

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