シヌスノードと心房不律
1From Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. rjohn2@partners.org.
Circulation
|May 12, 2016
まとめ
シヌスノード機能障害 (SND) と心房細動 (AF) は,共同心房改造のためにしばしば共存する. SNDとAFの治療は,AFまたは線維性心筋病気が優位であるかどうかにかかっています.
科学分野:
- 心臓病科
- 電気生理学
- アトリアル病理学
背景:
- シヌスノード機能障害 (SND) と心房不律,特に心房細動 (AF) はしばしば共存する.
- SNDとAFを結びつける正確なメカニズムは,まだ完全に理解されていません.
- この2つの状態は 心臓の構造と電気の改造を伴うものです
研究 の 目的:
- シヌスノード病理学に関する現在の知識をレビューする.
- 副鼻腔節疾患と心房不律の複雑な関係を解明する.
- 病気のフェノタイプに基づく 量身の治療戦略を策定する.
主な方法:
- SNDとAFに関する現代の研究の文献レビュー.
- 遺伝的および構造的要因を含む病理生理学的メカニズムの分析
- 統合されたSNDとAFの治療方法に関する情報の統合
主要な成果:
- SNDはAFからの電気的改造によって引き起こされるか,両方の状態が進行的な心房構造改造によって発生する可能性があります.
- 心房細動はしばしば左心房のトリガーと基板と関連しています.
- シヌス節の機能障害は 構造的な変化に結びついています 特に右心房です
結論:
- SNDとAFの治療戦略は,主たる表型に基づいて個別化されなければならない.
- AFと二次性SNDの患者にはカテーテル除去が有益です.
- 心臓のペースを調節する治療は,心房線維性心筋病気が優勢である患者の主要な治療法です.
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