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Site-Specific Lysine Lactylation via Genetic Code Expansion in E. coli and Mammalian Cells
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リンコサミド抗生物質のPLP依存型システニル処理の差異により,S機能化が異なった

Min Wang1, Qunfei Zhao1,2, Qinglin Zhang3

  • 1State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.

Journal of the American Chemical Society
|May 13, 2016
PubMed
まとめ

ピリドクサル5'- リン酸 (PLP) に依存する酵素CcbFとLmbFはシステイン中間物質を異なった形で変異させ,リンコサミド抗生物質の異なる構造を生み出します. この酵素の多様性は,新種のハイブリッド抗生物質の組み合わせ生物合成を可能にします.

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