低所得者の生息地における相互接続した微生物群と抵抗群
Erica C Pehrsson1, Pablo Tsukayama1, Sanket Patel1,2
1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Nature
|May 13, 2016
まとめ
抗生物質耐性遺伝子は 人間と環境の間 特に低所得地域で広がります この感染拡大を理解することは公衆衛生と感染管理に不可欠です
科学分野:
- 微生物学
- 環境科学
- 公衆衛生
背景:
- 抗生物質耐性感染症は 世界的な健康危機であり 微生物間の遺伝子転送によって悪化しています
- 人間と環境の貯水池の間の耐性遺伝子の拡散をマッピングすることは不可欠です.
研究 の 目的:
- 低所得者コミュニティのヒトと環境サンプルにおける細菌のコミュニティと抵抗性遺伝子交換の特徴を特定する.
- 主要な抵抗性遺伝子と,生息地間の拡散に関与する移動性遺伝子要素を特定する.
- 排泄物管理戦略がバクテリアと耐性遺伝子の減少に与える影響を評価する.
主な方法:
- 人間の糞便と環境サンプルからの細菌コミュニティ構造と抵抗体の分析.
- 抵抗性遺伝子の識別と移動性遺伝子要素との関連
- 低所得国や中所得国における排泄物管理の評価
主要な成果:
- レジストームは主に生態学的グラデーションに沿って細菌の系統学によって構成されています.
- 特定の抵抗性遺伝子は生息地の境界を越えることが判明し,しばしば移動性遺伝子の要素と結びついています.
- 排泄物管理の戦略は,糞便の細菌と抵抗性遺伝子の減少に異なる効果を示した.
結論:
- 細菌の系統形成はレジストームの構造に影響しますが,重要な遺伝子は生息地全体に広がります.
- 移動性遺伝子は 抗生物質耐性遺伝子の拡散を促進します
- 発見は,世界的な環境における耐性遺伝子の拡散のリスク評価と監視に役立つ.
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