関連する実験動画
Updated: Mar 21, 2026
06:20
Syngeneic Mouse Orthotopic Allografts to Model Pancreatic Cancer
Published on: October 4, 2022
4.2K
SIRT6は,Lin28bの制御によって臓がんを抑制する
Sita Kugel1, Carlos Sebastián1, Julien Fitamant1
1The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA 02114, USA.
Cell
|May 17, 2016
まとめ
Sirtuin 6 (SIRT6) は,ミクロRNA経路であるLin28bを調節することによって,臓がんを抑制する. SIRT6の喪失はPDACの進行と転移を促進し,患者のサブセットで治療標的を特定します.
科学分野:
- 腫瘍学
- エピジェネティクス
- 分子生物学
背景:
- 染色体改造タンパク質は がんではしばしば調節不能である.
- これらのタンパク質の腫瘍形成の役割,特に臓管内腺がん (PDAC) の役割は十分に理解されていません.
研究 の 目的:
- 管腺がん (PDAC) の抑制におけるシルトゥイン6 (SIRT6) の表遺伝的役割を調査する.
- SIRT6がPDACの進行と転移に影響を与える分子メカニズムを特定する.
主な方法:
- PDACにおけるSIRT6の機能を,分子と表遺伝子解析を用いて調査した.
- SIRT6活性に対するLin28bとlet-7マイクロRNA経路の調節を調べた.
- リン28bプロモーターにおけるヒストンの改変と転写因子の徴集を分析した.
主要な成果:
- SIRT6の不活性化により,PDACの進行と転移が加速する.
- SIRT6の喪失は,ヒストンの過酸化と,Lin28bプロモーターにおけるMycの募集によって,Lin28bのアップレギュレーションにつながります.
- このエピジェネティックプログラムは,PDAC症例の30%から40%で観察され,予後が悪いこととLin28b依存と相関しています.
結論:
- SIRT6はPDACにおける腫瘍抑制剤として作用する.
- 特定されたSIRT6- Lin28bの表遺伝子経路は,PDACの発現に不可欠であり,特定の患者の潜在的治療標的である.
関連する概念動画
01:12Loss of Tumor Suppressor Gene Functions
6.2K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.2K
03:03mTOR Signaling and Cancer Progression
5.0K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
5.0K
03:03mTOR Signaling and Cancer Progression
1.6K
1.6K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
10.0K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
10.0K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
2.9K
2.9K
01:22PI3K/mTOR/AKT Signaling Pathway
6.2K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
6.2K