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Updated: Mar 21, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
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Ru3 ((CO) 12) 触媒によるオルトメタレーション戦略によるメタ選択的CAr-H窒素化

Zhoulong Fan1,2, Jiabin Ni1,2, Ao Zhang1,2

  • 1CAS Key Laboratory of Receptor Research, and Synthetic Organic & Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences , Shanghai 201203, China.

Journal of the American Chemical Society
|May 17, 2016
PubMed
まとめ

研究者は,アルネのメタ選択的CAr-H窒素化のための新しいルテニウム触媒方法を開発した. この効率的なアプローチでは 簡単に手に入る材料を用いて 医薬品の合成を迅速に行うことができます

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All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
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