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Updated: Mar 21, 2026

High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy
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High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy

Published on: February 7, 2019

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ヒトの転写プロモーター開口の近原子解像度可視化

Yuan He1,2, Chunli Yan3, Jie Fang4

  • 1Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

Nature
|May 20, 2016
PubMed
まとめ

クリオ電子顕微鏡では,転写開始時にヒトの前開始複合体 (PIC) の構造を明らかにします. 連続した形状の変化と,泡の安定化におけるTFIIBと,DNAの解き放たれにおけるXPBの役割を示している.

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