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Updated: Mar 20, 2026

Anaerobic Protein Purification and Kinetic Analysis via Oxygen Electrode for Studying DesB Dioxygenase Activity and Inhibition
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Anaerobic Protein Purification and Kinetic Analysis via Oxygen Electrode for Studying DesB Dioxygenase Activity and Inhibition

Published on: October 3, 2018

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グリコペプチド抗生物質の生物合成に関与するP450酸化カスケードの調節

Madeleine Peschke1, Kristina Haslinger1, Clara Brieke1

  • 1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research , Jahnstrasse 29, 69120 Heidelberg, Germany.

Journal of the American Chemical Society
|May 24, 2016
PubMed
まとめ

この研究では,サイトクロームP450酵素が,NRPSX領域の同じ部位に結合することによって,グリコペプチド抗生物質 (GPA) を変化させる方法を明らかにした. 一つのモデルは,GPAの生物合成のための連続的な酵素募集とペプチドスキャニングを提案する.

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