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Updated: Mar 20, 2026

Author Spotlight: Advancing Techniques and Discoveries in Protein Synthesis and Assembly Through Innovative Mitochondrial Research
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Author Spotlight: Advancing Techniques and Discoveries in Protein Synthesis and Assembly Through Innovative Mitochondrial Research

Published on: June 7, 2024

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同期したミトコンドリアと細胞翻訳プログラム

Mary T Couvillion1, Iliana C Soto1, Gergana Shipkovenska1

  • 1Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|May 27, 2016
PubMed
まとめ

ミトコンドリアのエネルギー生産には 核とミトコンドリアの遺伝子の調整が必要です この研究では,核ゲノムがミトコンドリアと細胞細胞の変換を効率的な酸化リン酸化複合体の合成に導いていることが明らかになった.

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Mitochondria are double-membrane organelles of the eukaryotes involved in cellular metabolism, signaling, ATP synthesis, and programmed cell death.  Each of these processes requires specific proteins and enzymes that must be correctly sorted to the right mitochondrial subcompartment for the proper functioning of the organelle.
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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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