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Updated: Mar 20, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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プログラムされたラジカルカスケードによるオフィオボリン・セステルペンのエナンチオセレクティブ合成

Zachary G Brill1, Huck K Grover1, Thomas J Maimone2

  • 1Department of Chemistry, University of California, Berkeley, 826 Latimer Hall, Berkeley, CA 94702, USA.

Science (New York, N.Y.)
|May 28, 2016
PubMed
まとめ

研究者は複雑なテルペンを合成する新しいラジカルサイクライゼーション方法を開発し,天然製品合成の課題を克服しました. このアプローチは,溶融リングシステムを効率的に作成し,細胞毒性化合物の全合成を可能にします.

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Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
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Epoxidation of alkenes via oxidation with peroxy acids involves the conversion of a carbon–carbon double bond to an epoxide using the oxidizing agent meta-chloroperoxybenzoic acid, commonly known as MCPBA. Since the O–O bond of peroxy acids is very weak, the addition of electrophilic oxygen of peroxy acids to...
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