甲状腺がん
Maria E Cabanillas1, David G McFadden2, Cosimo Durante3
1Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lancet (London, England)
|June 1, 2016
まとめ
甲状腺がんの発生率は 世界的に上昇しています 差別化型甲状腺がんは標準的な治療法で治療できるが,髄膜がんやアナプラスティック型甲状腺がんのような稀なタイプは,進行する病気の特殊なケアと標的治療を必要とします.
科学分野:
- 腫瘍学
- 内分泌学
背景:
- 甲状腺がんは 世界的に深刻な健康問題となっています
- 差別化された甲状腺がん (DTC) は最も一般的なサブタイプで,標準的な治療は一般的に効果的です.
- 甲状腺髄性がん (MTC) と アナプラスティック甲状腺がん (ATC) を含む希少なサブタイプは,ユニークな課題を提示します.
研究 の 目的:
- 甲状腺がんの発生と治療の現状をまとめます
- 異なる甲状腺癌のサブタイプに対する 異なる管理戦略を強調する.
- 進行または進行中の甲状腺がんにおける標的治療の役割について議論する.
主な方法:
- 甲状腺がんの発生率に関する疫学データのレビュー
- 分化性甲状腺がんの標準治療プロトコルの分析
- 甲状腺の髄膜がんとアナプラスティックがんの専門的なアプローチの検討
- 進行した甲状腺がんに対する承認された標的治療法の評価
主要な成果:
- 甲状腺がんの発生率は 世界中で増加しており 米国女性では5番目に多い癌です
- DTCの標準的な治療法 (手術と放射性ヨウ素または観察) は,ほとんどの患者にとって有効です.
- DTCとMTCの標的治療は,進行性のない生存を延ばすことができますが,治療は進行性または症状のある症例に留められています.
結論:
- 甲状腺がんの効果的な管理は,正確なサブタイプと適切な治療法の選択に依存します.
- 希少で攻撃的な甲状腺癌のサブタイプを管理するには 専門的な専門知識が不可欠です
- ターゲティングセラピーは 進行した病気の治療に 利点をもたらしますが 治療法への継続的な研究の必要性を強調しています
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