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Updated: Mar 20, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
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ヒスティジン誘導のアリレーション/銅媒介の骨幹N-H結合のアルケニル化 (II)

Jun Ohata1, Matthew B Minus1, Morgan E Abernathy1

  • 1Department of Chemistry, Rice University , Houston, Texas 77005, United States.

Journal of the American Chemical Society
|June 2, 2016
PubMed
まとめ

研究者はペプチドとタンパク質の骨組みを 改造する新しい銅媒介反応を開発しました この方法は,ヒスティジン残基を使用して,N-アルケニル化またはN-アリレーションを指示し,タンパク質工学の新しいツールを提供します.

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Simple aryl halides do not react with nucleophiles. However, nucleophilic aromatic substitutions can be forced under certain conditions, such as high temperatures or strong bases. The mechanism of substitution under such conditions involves the highly unstable and reactive benzyne intermediate. Benzyne contains equivalent carbon centers at both ends of the triple bond, each of which is equally susceptible to nucleophilic attack. This 50–50 distribution of products is...
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