産業用メラニズム変異は,イギリスの変異因子である
Arjen E Van't Hof1, Pascal Campagne1, Daniel J Rigden1
1Institute of Integrative Biology, University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7ZB, UK.
Nature
|June 3, 2016
まとめ
産業用メラニズムを引き起こす変異は 皮質遺伝子に挿入できる要素でした この挿入は 1819年頃 皮質の遺伝子発現を高め 汚染への適応を促しました
科学分野:
- 進化生物学
- 遺伝学
- 分子生物学
背景:
- 工業用メラニズムであるビストン・ベトゥラリアは 適応の典型的な例です
- メラニック (炭酸性) の形態の遺伝的基礎は局所化されているが,特定されていない.
- この目に見える進化的反応を 駆動する変異を理解することは 極めて重要です
研究 の 目的:
- 産業用メラニズムの原因となる 特定の変異を特定する
- この変異が表型変化を引き起こす分子メカニズムを解明する.
- 変異のタイミングを判断する
主な方法:
- カルボナリアの位置を 細かくマッピングする
- 遺伝子の違いを特定するための配列分析
- 移行のタイミングの統計的推論
- 遺伝子発現の変化の分析
主要な成果:
- 変異は,皮質遺伝子の最初のイントロンに挿入された大きな,タンデムで繰り返されるトランスポーザブル要素です.
- 統計的分析によると,この移行は1819年頃に行われた.
- 置換可能な要素は,皮質のトランスクリプトの豊富さを増加させる.
- 皮質のタンパク質は,翼の発達中の細胞循環の調節に関与しています.
結論:
- この発見は 産業用メラニズムを誘発する 特定の変異を特定しました
- 転置可能な要素は,主要な現象的新しさと迅速な適応の源となる可能性があります.
- この発見は 進化の象徴的な出来事を 分子的に説明します
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