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Updated: Jan 18, 2026

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
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Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

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EGFR (T790M) とEGFR (C797S) 抵抗を突变選択性アロステリック阻害剤で克服する

Yong Jia1, Cai-Hong Yun2,3, Eunyoung Park2,3

  • 1Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.

Nature
|June 3, 2016
PubMed
まとめ

薬剤耐性表皮成長因子受容体 (EGFR) 変異を標的とした新しいアロステリック阻害剤,EAI045は,非小細胞肺がんの治療に有望である. セトゥキシマブと併用すると,臨床前モデルにおける耐性EGFR変異を効果的に抑制します.

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Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure09:38

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