宿主-微生物群の相互性における協力的微生物耐性行動
1Nomis Center for Immunobiology and Microbial Pathogenesis, the Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Cell
|June 4, 2016
まとめ
病原菌のように 有益な微生物は 宿主の操作を 自分の健康のために使います この観点からすると これらの行動が宿主の健康と耐性を促進し 協力的な宿主-微生物の進化を促進します
科学分野:
- 微生物学
- 進化生物学
- 宿主 と 微生物 の 相互作用
背景:
- 細菌に対する動物の防御は 伝統的に免疫システムの抵抗メカニズムに焦点を当てています
- この敵対的な見方は 有益な宿主-微生物の関係を理解することを困難にします
- 病原性の微生物は 宿主の代償で体調を向上させる行動を示します
研究 の 目的:
- 宿主と微生物の相互作用のための補完的な枠組みを提案する.
- 有益な微生物は 宿主のプロセスを操作する 行動も進化させています
- これらの行動が 宿主の健康と微生物の健康を 促進する方法を調べるためです
主な方法:
- 宿主-微生物のダイナミクスに関する既存の研究の概念分析と合成.
- 病原体と有益な相互作用の両方の文脈で微生物の行動を探求する.
- 宿主-微生物システムの進化動態の理論モデル化.
主要な成果:
- 有益な微生物が病原体に似た行動をとる 提案された枠組みです
- これらの行動は 害ではなく 宿主の耐性や健康を 促進することを示唆しています
- この微生物の二重な役割は 協力的な進化のダイナミクスにつながります
結論:
- 有益な微生物は,宿主の健康促進を通じて,宿主のプロセスを操作して,体調を高めることができます.
- 伝統的に病原性に関連した微生物の行動も宿主耐性を引き起こす可能性があります.
- この見方は宿主と微生物の共同進化を支持しています
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