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Updated: Mar 19, 2026

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy
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ナノディスクのTRPV1構造は,リガンドと脂質の作用のメカニズムを明らかにする

Yuan Gao1,2, Erhu Cao1, David Julius1

  • 1Department of Physiology, University of California, San Francisco, California 94143, USA.

Nature
|June 10, 2016
PubMed
まとめ

ネズミのTRPV1イオンチャネルを冷凍EMとナノディスクで調べると,脂質相互作用が明らかになった. 特定のフォスフォリピドは毒素結合を調節し,カプサイシンのような分子を置換することによってチャネル活性化を制御する可能性があります.

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