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Updated: Mar 19, 2026

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
10:09

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

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p53 と c-MYC の二重標的化は,白血病幹細胞を選択的に排除する

Sheela A Abraham1, Lisa E M Hopcroft1, Emma Carrick2,3

  • 1Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Gartnavel General Hospital, 1053 Great Western Road, Glasgow G12 0YN, UK.

Nature
|June 10, 2016
PubMed
まとめ

BCR-ABLではなくp53とc-MYCをターゲットにすることで,慢性骨髄性白血病 (CML) の白血病幹細胞 (LSC) を根絶します. この精密医療のアプローチは LSC を排除しながらも 正常な幹細胞を保存し 新しくCML治療の戦略を提示します

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