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Updated: Nov 3, 2025

Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
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Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors

Published on: November 4, 2019

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幹 細胞: 人 の 生物学 研究 の 復興

Jun Wu1, Juan Carlos Izpisua Belmonte2

  • 1Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA 92037, USA; Universidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos, 135, Guadalupe 30107, Murcia, Spain.

Cell
|June 18, 2016
PubMed
まとめ

単細胞オミクスや 幹細胞研究のような新しい技術は 人間の生物学に対する理解を 革命的に変えています これらの進歩は 発達と病気に関する 前例のない 分子洞察力を提供し 新しい治療法への道を開きます

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Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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