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Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
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グルココルチコイドとプロゲステロンに特異的な効果は,それぞれのホルモン受容体の異なる発現によって決定されます

U Strähle1, M Boshart, G Klock

  • 1Deutsches Krebsforschungszentrum, Institut für Zell- und Tumorbiologie, Heidelberg, FRG.

Nature
|June 22, 1989
PubMed
まとめ

グルココルチコイド受容体やプロゲステロン受容体などのホルモン受容体は,同じDNA配列に結合します. プロゲステロン受容体を細胞に導入することで,遺伝子発現が再プログラムされ,異なる受容体発現が示され,ステロイド選択性が達成されます.

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