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Updated: Mar 19, 2026

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
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Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Published on: March 31, 2022

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Hsp90-Cdc37-Cdk4の原子構造は,Hsp90が展開されたキナーゼを捕まえて安定させることを示している

Kliment A Verba1, Ray Yu-Ruei Wang1, Akihiko Arakawa2

  • 1Howard Hughes Medical Institute (HHMI) and the Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.

Science (New York, N.Y.)
|June 25, 2016
PubMed
まとめ

熱ショックタンパク質90 (Hsp90) とそのコチャペロンCdc37は,Cdk4のようなクライアントキナーゼを安定させる. この研究は,Hsp90とCdc37トラップキナーゼの構造を明らかにし,展開状態を示しています.

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