合成後の7つの共性反応で,メタル・オーガニック・フレームワーク・クリスタル内の酵素のような複雑性が生じる
Alejandro M Fracaroli1,2,3, Peter Siman1,2, David A Nagib1
1Department of Chemistry, University of California , Berkeley, California 94720, United States.
Journal of the American Chemical Society
|June 28, 2016
まとめ
研究者は7つの合成後の反応を用いて,金属有機フレームワーク (MOF) の内部で複雑な酵素のような活性サイトを作成しました. MOFは 酵素の機能を真似て 複雑な化学反応を行うことができます
科学分野:
- 材料科学
- 超分子化学
- 化学工学
背景:
- メタル・オーガニック・フレームワーク (MOF) で酵素のような複雑性を設計することは困難です.
- 構造を損なうことなく,MOFの毛穴内で複数の合成後の反応を達成することは困難です.
研究 の 目的:
- MOF内で複数の合成後の反応を実行する可能性を実証する.
- トリペプチドをMOFの毛穴に共性的に組み込み,酵素のような活性サイトを作成します.
- 達成された複雑性の触媒活動への影響を調査する.
主な方法:
- 多変量MOFであるMTV-IRMOF-74-IIIを合成後の改変に使用した.
- MOFの毛穴内でのトリペプチドの7つの連続的共性組み込み反応を行った.
- タンデム反応では,アロマティックアミン (-NH2) よりもプライマリアミン (-CH2NHBoc) の反応性が高い.
主要な成果:
- MTV-IRMOF-74-III MOF内で7つの合成後の反応を成功裏に実行しました.
- H2N-Pro-Gly-Ala-CONHLとH2N-Cys-His-Asp-CONHLの配列をMOF有機ストラットに共用的に組み込みました.
- 多段階の反応過程で,MOFの多孔性と結晶性が維持される.
- 酵素のような触媒能力を示唆する,改造されたMOFの反応性の変化の予備証拠を観察した.
結論:
- MOFの多段階の機能化のための堅固な方法を示した.
- MOF内の空間的にも構成的にも異質な酵素模倣活性サイトを成功裏に作成した.
- 開発されたMOFプラットフォームは,以前は酵素を必要とする反応を触媒化する可能性を示している.
関連する概念動画
02:58Crystal Field Theory - Octahedral Complexes
30.8K
Crystal Field Theory
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
30.8K
02:34Enzymes
94.7K
Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
94.7K
02:46Crystal Field Theory - Tetrahedral and Square Planar Complexes
48.5K
Tetrahedral Complexes
Crystal field theory (CFT) is applicable to molecules in geometries other than octahedral. In octahedral complexes, the lobes of the dx2−y2 and dz2 orbitals point directly at the ligands. For tetrahedral complexes, the d orbitals remain in place, but with only four ligands located between the axes. None of the orbitals points directly at the tetrahedral ligands. However, the dx2−y2 and dz2 orbitals (along the Cartesian axes) overlap with the ligands less than the dxy,...
Crystal field theory (CFT) is applicable to molecules in geometries other than octahedral. In octahedral complexes, the lobes of the dx2−y2 and dz2 orbitals point directly at the ligands. For tetrahedral complexes, the d orbitals remain in place, but with only four ligands located between the axes. None of the orbitals points directly at the tetrahedral ligands. However, the dx2−y2 and dz2 orbitals (along the Cartesian axes) overlap with the ligands less than the dxy,...
48.5K
02:51Metal-Ligand Bonds
24.3K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
24.3K
02:04Covalently Linked Protein Regulators
9.6K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
These groups modify specific amino acids in a protein....
9.6K
01:29Covalent Bonds
162.3K
Overview
162.3K