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Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
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細胞内マルチターゲティングの支柱として,細胞に浸透するペプチドミミックとディスプレイと配信機能を統合する

Yugang Bai, Lien Nguyen, Ziyuan Song

  • 1Laboratory of Drosophila Research and School of Life Sciences, The Chinese University of Hong Kong , Shatin, New Territories, Hong Kong SAR, China.

Journal of the American Chemical Society
|June 30, 2016
PubMed
まとめ

毒性RNAのリピートを標的とする多価リガンドは,ミオトニック・ディストロフィーI型 (DM1) の新たな治療戦略を提供します. これらの化合物はRNAの焦点とスプライシングの欠陥を阻害し,この神経筋疾患の治療に希望を示しています.

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