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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
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Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

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Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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持続 し た 腹: 臨床 的 な 検討

Herbert L DuPont1

  • 1University of Texas School of Public Health and Medical School, Houston2Kelsey Research Foundation, Houston, Texas3Baylor College of Medicine, Houston, Texas.

JAMA
|July 1, 2016
PubMed
まとめ

14日以上続く慢性的な下痢は,急性疾患とは異なる感染因子によるものです. 正確な診断は この認知されていない状態の 効果的な治療に不可欠です

科学分野:

  • 医学微生物学
  • 感染症
  • 胃腸内科

背景:

  • 下痢性疾患は一般的ですが,持続性下痢 (≥14日) は異なる病因を伴います.
  • これらの原因を理解することは,適切な臨床管理と患者のアウトカムにとって不可欠です.

研究 の 目的:

  • 感染症によって引き起こされる持続的な下痢の流行病学,病因学,診断および管理をレビューする.
  • 世界中で免疫能力のある個人に効果的な治療のための正確な診断の重要性を強調する.

主な方法:

  • 開発途上国や旅行者に関する研究から得られたデータのレビュー
  • 細菌や寄生虫の病原体について
  • 培養依存,培養独立 (PCR),顕微鏡検査を含む診断方法についての議論.

主要な成果:

  • 発展途上国への旅行者の約3%が 慢性的な下痢を患っています
  • 主な病原体には,ギアルディア,クリプトスポリジウム,腸内結合性大腸菌,シゲラが含まれます.
  • スキストソーマ種は,固有の地域で発見される稀な原因です.

結論:

  • 持続的な下痢は 十分に認識されていない症候群で 徹底的な評価が必要である.

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  • 正確な病因診断は,治療の成功と症状の改善に不可欠です.