ベース前頭脳からの投影は,横のヘブンヌラに,攻撃報酬を調節する
Sam A Golden1,2, Mitra Heshmati1,2, Meghan Flanigan1,2
1Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Nature
|July 1, 2016
まとめ
研究者達は 攻撃性の報酬的な側面を制御する 基礎前頭脳から側頭葉への経路 (BF-lHb) を 特定しました この経路は 攻撃的行動の動機を 制御するものです 攻撃的行動の始まりを 制御するわけではありません
科学分野:
- 神経科学
- 行動神経科学
- 攻撃性の神経生物学
背景:
- 適応不良の攻撃は 神経精神疾患と関連しており 社会的刺激に反応する脳の報酬システムが 調節不能になっていることがよくあります
- 攻撃を誘発する脳の領域は知られていますが 攻撃の動機付け要素を制御する神経機構は不明です
研究 の 目的:
- 攻撃的な行動の動機付けを 調節する神経回路を調査する
- 男性同士の攻撃的な相互作用の報酬特性を測定するためのマウスモデルを確立する.
主な方法:
- 男性マウスの攻撃的行動に対する社会的報酬として,従属の侵入者を用いた条件付き場所偏好 (CPP) パラダイムを開発した.
- 基礎前脳 (BF) から側頭葉 (lHb) へのGABAergic投影を選択的に活性化または静止するために,光遺伝学 (ハロドプシンとチャネルロドプシン) を利用した.
- ニューロンの発火とCPP/条件付きの場所嫌悪 (CPA) の変化を測定し,攻撃的相互作用のバレンスを評価した.
主要な成果:
- 攻撃的なマウスは侵入者に関連したCPPを発現し,非攻撃的なマウスはCPAを発現した.
- アグレッサーにおけるGABAergic BF- lHb経路を静止すると,lHbの活性が増加し,CPPは廃止された.
- GABAergic BF- lHb経路の活性化により,攻撃性の開始に影響を与えることなく, lHbの活性が低下し,CPPが誘発された.
結論:
- GABAergic BF-lHb回路は,男性間の攻撃的行動の動機付けの価値 (報酬値) を双方向的に制御する.
- この回路は,特に"好み"や行動の開始とは関係なく, 攻撃に関連した"欲"や報酬の処理を調節します.
- 攻撃性報酬のニューラル基盤に関する新しい洞察を提供し,関連する神経精神疾患を理解するために重要です.
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