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Development of the Heart

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...

Structure of Cardiac Muscles

Structure of Cardiac Muscles

Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Updated: Mar 18, 2026

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

心筋細胞の相互作用を調整し,心室の形態変異を誘導する

Peidong Han¹, Joshua Bloomekatz¹, Jie Ren¹

¹Department of Medicine, Division of Cardiology, University of California, San Diego, La Jolla, California 92093, USA.

|July 1, 2016

まとめ

心室内壁への心筋細胞の組み立てには,ノッチとErbb2のシグナリングの間のフィードバックループが含まれます. このプロセスは細胞の位置づけをガイドし心臓の適切な構造と機能を保証します

さらに関連する動画

Analysis of Cardiac Chamber Development During Mouse Embryogenesis Using Whole Mount Epifluorescence

Analysis of Cardiac Chamber Development During Mouse Embryogenesis Using Whole Mount Epifluorescence

Published on: April 17, 2019

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart

Published on: March 26, 2015

関連する実験動画

Last Updated: Mar 18, 2026

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

Analysis of Cardiac Chamber Development During Mouse Embryogenesis Using Whole Mount Epifluorescence

Analysis of Cardiac Chamber Development During Mouse Embryogenesis Using Whole Mount Epifluorescence

Published on: April 17, 2019

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart

Published on: March 26, 2015

科学分野:

心血管生物学
発達生物学
セルラー・シグナル

背景:

心臓の心室壁には機能に欠かせないコンパクトでトラベキュラー層があります
心筋の壁の形成の障害は先天性心疾患と心筋病を引き起こす.
胚性心筋細胞の空間的組織化のメカニズムは,ほとんど不明である.

研究の目的:

発達中のゼブラフィッシュの心臓における心臓肌細胞集合を制御するシグナル伝達経路を解明する.
細胞の位置づけと形態変異を導くために,心筋のNotchとErbb2のシグナル伝達がどのように相互作用するかを理解する.
腹腔壁の形成の細胞動態を明らかにするために

主な方法:

先進的な遺伝子操作とゼブラフィッシュモデルにおける in vivo 画像を用いた
NotchとErbb2の信号伝達の細胞自律的および非細胞自律的役割を調査した.
心筋のノッチ活動が心室形状に及ぼす影響を分析した.

主要な成果:

心臓のnotchシグナルがErbb2シグナルを阻害し,心筋細胞の芽生えとトラベキュレーションを防ぐフィードバックループを特定しました.
心筋特異的なノッチ不活性化により,心室のサイズが縮小し,心室の壁が太った.
広範囲に広がった心筋突起の活動により細い壁の心室が膨張しトラベキュラが欠けていた.
Erbb2活性化された心筋細胞は,非細胞的に心筋のNotch信号を活性化します.

結論:

ノッチとErbb2の間の新しいインタラクティブな細胞フィードバックプロセスは,心筋細胞の組み立てを導く.
このシグナル相互作用は,心室壁の空間的次元と心筋質量を確立するために重要です.
発見は組織形態変異と臓器形成の細胞動力学に関する洞察を提供します.