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Author Spotlight: Developing Tools to Tune the Activity of Tyrosine Phosphatases
06:56

Author Spotlight: Developing Tools to Tune the Activity of Tyrosine Phosphatases

Published on: September 6, 2024

558

SHP2フォスファタゼのアロステリック阻害は,受容体チロシンキナーゼによって引き起こされる癌を阻害する

Ying-Nan P Chen, Matthew J LaMarche, Ho Man Chan

    Nature
    |July 1, 2016
    PubMed
    まとめ

    SHP099という新しい小分子阻害剤は,がん誘発性タンパク質チロシンファスファターゼ (SHP2) を効果的に標的にします. この発見は,RASERK経路を通じて腫瘍細胞の増殖を抑制することで,様々な癌に対する有望な治療戦略を提供します.

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