関連する実験動画

Updated: Mar 18, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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Gタンパク質からGPCRにおけるアゴニスト結合ポケットへのアロステリック結合

Brian T DeVree, Jacob P Mahoney, Gisselle A Vélez-Ruiz

    Nature
    |July 1, 2016
    PubMed
    まとめ

    Gタンパク質結合受容体 (GPCRs) は,Gタンパク質結合時に閉ざされた形状を安定させ,アゴニストなしでリガンド結合に影響を与えます. このGタンパク質の相互作用は,多くのGPCRに対するアゴニストの親和性を高めます.

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