マラリア 蚊 アノフェレス・ガンビア の 男性 性 の 遺伝子
Elzbieta Krzywinska1, Nathan J Dennison2, Gareth J Lycett3
1The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, UK.
Science (New York, N.Y.)
|July 2, 2016
まとめ
研究者たちは アノフェレス・ガンビア蚊の雄性決定因子として ヨブ遺伝子を特定しました この遺伝子は性決定を制御し,マラリアの制御のための雄性蚊の株を作成するために使用することができます.
科学分野:
- 遺伝学
- 分子生物学
- 昆虫学
背景:
- 性別決定の分子メカニズムは種によって異なる.
- 多くの昆虫では,Y染色体に関連したM因子が男性性を決定するが,その性質はしばしば不明である.
- マラリア蚊 アノフェレス・ガンビアは 昆虫の性決定を研究するための 重要なモデルです
研究 の 目的:
- アノフェレス・ガンビアの男性性の原因となるM因子を特定し特徴づけること.
- 胚の発達と性決定における この因子の役割を理解する.
- マラリア対策戦略における応用の可能性を調査する.
主な方法:
- アノフェレス・ガンビアにおけるヨブの遺伝子分離と特徴づけ.
- 胚の発達中のヨブ遺伝子発現パターンの分析
- 実験的にヨブの表情を 静音化や子宮外出で操作する
主要な成果:
- ヨブ遺伝子は,アノフェレス・ガンビアの男性性を制御するM因子として識別された.
- ヨブはジゴティック転写の初期に活性化され,男性の発達に不可欠です.
- Yobは男性特有の 双性遺伝子の結合を制御しています
- エクトピック発現は男性のみの子孫を生み出します
結論:
- ヨブ遺伝子は,アノフェレス・ガンビアの男性性の主要な決定因子です.
- ヨブの重要な役割と 女性を殺す性質は 遺伝子制御のための新しいツールを提供します
- この発見は,マラリアのベクトル制御のためのトランスジェニックのアノフェレス菌株の開発に重要な意味を持っています.
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