EMT: 2016 年
M Angela Nieto1, Ruby Yun-Ju Huang2, Rebecca A Jackson3
1Instituto de Neurociencias CSIC-UMH, Avda. Ramón y Cajal s/n, 03550 San Juan de Alicante, Spain.
Cell
|July 2, 2016
まとめ
細胞の可塑性は,上皮-メゼンキマ移行 (EMT) を含め,胚の発達と病気を駆動する. EMT を理解する
科学分野:
- 細胞の可塑性と発達生物学
- 癌研究と病理学
- 分子生物学と細胞生物学
背景:
- 胚の発達と疾患の進行において,上皮-メゼンキマ移行 (EMT) は極めて重要です.
- EMTはダイナミックな状態のスペクトルであり 単純なバイナリースイッチではありません
- EMTとその中間状態は臓器線維症と腫瘍の進行に関与しています
研究 の 目的:
- EMTにおける細胞の可塑性と異質性の現在の理解をレビューする.
- EMTの研究における最近の発見と継続的な課題を強調する.
- 癌や線維症のような人間の病気に EMTの影響を議論する.
主な方法:
- EMTに関する現在の研究の文献レビューと要約.
- 重要な概念の議論:細胞の可塑性,異質性,そして移行状態.
- 発育,線維症,がんの進行におけるEMTの役割の分析
主要な成果:
- EMTは細胞状態の連続体であり 単一の移行ではありません
- EMTとその中間状態は臓器線維症と腫瘍の進行の主要な要因です.
- 転移性コロニー化におけるEMTの役割は慎重に解釈する必要があります.
結論:
- 細胞の可塑性 特にEMTは 複雑な病気を理解する上で 根本的な役割を果たします
- EMT分野における未解決の問題と課題を解決するためにさらなる研究が必要である.
- EMTの異質性と可塑性に関する継続的な調査は,病気の治療戦略を前進させるでしょう.
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