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Updated: Mar 18, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

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α 置換されたラクトームのNi-触媒化されたエナンチオセレクティブC-アサイレーション

Masaki Hayashi1, Shoshana Bachman1, Satoshi Hashimoto1

  • 1The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, California 91125, United States.

Journal of the American Chemical Society
|July 5, 2016
PubMed
まとめ

研究者は,エナチオセレクティブCアシレーションのための新しいニッケル触媒方法を開発しました. この戦略は,α-四分位置換ラクタム,特にβ-ケトラクタムを高エナティオメール過剰で効率的に合成します.

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