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Updated: Mar 18, 2026

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
11:44

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Published on: September 18, 2014

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ヘクソキナーゼは,バクテリアのペプチドグリカンを検出するための先天的な免疫受容体である

Andrea J Wolf1, Christopher N Reyes2, Wenbin Liang3

  • 1F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Cell
|July 5, 2016
PubMed
まとめ

グラム陽性細菌は,代謝酵素ヘクソキナーゼによって検出されるN-アセチルグルコサミンを介してNLRP3炎症体を活性化します. この発見は,パターン認識受容体として作用する代謝酵素を明らかにし,免疫反応に影響を与えています.

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